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Hizentra Dosing and Self-administration Information

Your patients are all different and deserve a treatment with the flexibility to fit their individual needs and preferences. Use the guidelines and dosing calculator below to initiate a patient's Hizentra therapy. Adjust the dose based on clinical response and serum immunoglobulin G (IgG) trough levels.

Hizentra vials

Starting Hizentra Treatment

  • For weekly or more frequent dosing, start Hizentra treatment 1 week after the last IVIg treatment or SCIg treatment
  • For biweekly (every 2 weeks) dosing, start treatment 1–2 weeks after the last IVIg infusion or 1 week after the last weekly SCIg infusion

Help Patients Start Hizentra With Confidence

Find information regarding self-infusion training to help your patients get started on Hizentra

Patient resources

Dosing Calculator

The Hizentra dosing calculator can help you rapidly determine an accurate recommended dose of Hizentra for your patients.

Simply complete the fields below and Calculate.

Patient Profile


1
Please enter a valid IVIg dose in grams
2
Enter a valid number of weeks between doses
3

Please enter a valid frequency
*To covert milliliters to grams, divide milliliters by 5.

Dosing Results


Based on an IVIg dose of [number] grams every [frequency] weeks, your Hizentra dose every [infusion] day(s) will be:

grams:
or
milliliters:

Here is the formula used by the calculator to determine a weekly dose:

Hizentra weekly dose formula

Over time, the dose may have to be adjusted to achieve the desired results. To determine if a dose adjustment is needed, measure the patient's serum IgG trough level 2 to 3 months after transitioning to Hizentra. To learn how to adjust the dose, please see the full Prescribing Information.

The goal is to achieve a systemic serum IgG exposure (area under the concentration-time curve) not inferior to that of the previous IVIg treatment (if applicable).

Here are the formulas for converting a weekly Hizentra dose to other frequencies:

Hizentra dosing formula for other frequencies

Guide for Administering Self-infused Subcutaneous Ig (SCIg) Therapy

Hizentra should be administered subcutaneously only. Do not administer intravenously. Hizentra can be dosed daily up to every 2 weeks, using an infusion pump and small needle(s).

Injection site chart
  • A Hizentra dose may be infused into multiple injection sites. Use up to 4 sites simultaneously or up to 12 sites consecutively per infusion. Infusion sites should be at least 2 inches apart. Change the actual site of infusion with each administration
  • Recommended infusion sites include the stomach, thighs, upper arms, or hips
  • SC needles are smaller than IV needles. Depending on a patient's size and weight, a needle as short as 4 mm or as long as 14 mm can be used
  • Infusion rate may be increased to 25 mL/hour per site as tolerated after the first infusion
  • Volume may be increased to 25 mL per site as tolerated after the fifth infusion
Up to 15 mL/hr for the first infusion. ≤15 mL/site for the first 4 infusions, then ≤20 mL/site for the 5th infusion.

Help Patients Infuse With Confidence

Step-by-Step Instructions for Self-administering Hizentra provide a useful tool for patients new to this treatment method.

Hizentra Infusion Guide Download the Infusion Guide
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