Dosing and Administration

Self-administered Hizentra lets you plan treatment around your patient's life

Your patients are all different and deserve a treatment with the flexibility to fit their individual needs and preferences. Use the guidelines and dosing calculator below to initiate a patient's Hizentra therapy. Monitor the patient's clinical response and adjust the duration of therapy based on patient need.

See how easy self-administration is with Hizentra

Watch a video that provides step-by-step instructions to
help patients infuse Hizentra.

Free online administration training is available for CIDP

SHARE Nurse Training for CIDP

Become a SHARE Hizentra administration specialist:

  • Complete training in about 1 hour at your convenience
  • Get a certificate of completion
  • Add your practice to the Nurse Locator so patients in your area can find you!

Start your SHARE training

Convenient dosing and self-administration for CIDP

Administration volumes and rates for Hizentra (as tolerated)

CIDP weekly
Infusion parameters*
1st infusion
Subsequent infusions
Volume (mL/site) ≤20 ≤50

Rate (mL/hr/site) ≤20 ≤50
*As tolerated

CIDP dosing calculator

1
Calculate Weekly Dose
lb
kg
Please enter a value between 1 and 499.

Recommended dose is 0.2 g/kg or 0.4 g/kg
Please enter a value between 0.1 and 1.0.
2
Calculate Infusion Time
Weekly dose XX g (XX mL)
Reset
5
(min)
50
(max)
+
Volume per site
Number of infusion sites
5
(min)
50
(max)
+

Number of infusion sites

sites

Number of sites cannot exceed 8 sites per infusion (per Hizentra Prescribing Information).
Please select a larger infusion volume or consider multiple infusion sites over multiple days.
1
(min)
8
(max)
+

Infusion volume

25 mL/site

Volume of infusions per site cannot exceed 50 mL (per Hizentra Prescribing Information).
Please select a higher number of infusion sites or consider multiple sessions over multiple days.
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Dosing Results
Infusion time*: XX hours and XX minutes Weekly dose XX g (XX mL)
Your results are based on a patient weight of XXX XX and dose of X.X g/kg

To see number of vials, select vial size:

1 g (5 mL)
2 g (10 mL)
4 g (20 mL)
10 g (50 mL)

Number of vials: XXX

*Infusion times can vary based on specific equipment used.

Formula used to calculate the weekly dose in mL from the patient's weight in kg:

For 0.2 g/kg dose (1:1 ratio)

Patient weight in kg = Weekly dose in mL

Example: 80 kg weight = Weekly dose of 80 mL

For 0.4 g/kg dose (1:2 ratio)

Patient weight in kg x 2 = Weekly dose in mL

Example: 80 kg weight = Weekly dose of 160 mL

Formula used to convert the weekly dose in mL to g:

Weekly dose in mL
5
= Weekly dose in g
Example: 80 mL = 16 g

Initiate therapy 1 week after last IVIg infusion

  • Recommended subcutaneous dose is 0.2g/kg (1 mL/kg) body weight (bw) per week
    • During PATH, both 0.2 g/kg and 0.4 g/kg doses were found to be safe and effective. Patients who relapsed were restabilized with IVIg
  • During the OLE study to PATH, patients who relapsed on 0.2 g/kg were titrated to 0.4 g/kg without IVIg restabilization

Proactively monitor and optimize therapy

  • Monitor the patient's clinical response and adjust the duration of therapy based on patient need
  • Volume and rate can be adjusted after initial infusion as tolerated, which may decrease infusion time and number of sites
  • Consider changing one variable at time (eg, rate, volume, ancillary supplies, site) to continue tailoring treatment for your patient
  • Hizentra may be infused in up to 8 infusion sites simultaneously, depending on volume

Administering Hizentra therapy

Hizentra should be administered subcutaneously only. Do not administer intravenously. Hizentra can be administered weekly for CIDP in 1 or 2 sessions over 1 or 2 consecutive days, using an infusion pump and relatively small needle(s).

Hizentra Injection Sites
  • A Hizentra dose may be infused into multiple injection sites. Use up to 8 sites per infusion. More than one infusion device can be used simultaneously. Infusion sites should be at least 2 inches apart. Change the actual site of infusion with each administration
  • Recommended infusion sites include the abdomen, thighs, upper arms, or side of upper leg/hip
  • SC needles are smaller than IV needles. Depending on a patient's size and weight, a needle as short as 4 mm or as long as 14 mm can be used

Encourage patients to start and stay on therapy

Information and resources are available to help patients manage their ongoing administration of Hizentra.

Managing therapy

Frequently asked questions about Hizentra

Want to know more about Hizentra? See answers to prescribers' frequently asked questions.

See the answers
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