Dosing and Administration

hizentra vials

Self-administered Hizentra lets you plan treatment around your patient’s life

Your patients are all different and deserve a treatment with the flexibility to fit their individual needs and preferences. Use the guidelines and dosing calculator below to initiate a patient's Hizentra therapy. Monitor the patient's clinical response and adjust the duration of therapy based on patient need.

See how easy self-administration is with Hizentra

Self-infusing with Hizentra prefilled syringes

Self-infusing with Hizentra vials

Free online administration training is available for PI

SHARE Nurse training PI image

Become a SHARE Hizentra administration specialist:

  • Complete training in about 1 hour at your convenience
  • Get a certificate of completion
  • Add your practice to the Nurse Locator so patients in your area can find you!

Start your SHARE training

Convenient dosing and self-administration for PI

PI Dosing and Administration Chart
*As tolerated

PI dosing calculator

Patient Profile

Please enter a valid IVIg dose in grams
Enter a valid number of weeks between doses

Please enter a valid frequency
To convert milliliters to grams, divide milliliters by 5.

Dosing Results

Based on an IVIg dose of [number] grams every [frequency] weeks, your Hizentra dose every [infusion] day(s) will be:


Formula used by the calculator to determine a weekly dose:

Initial weekly recommended dose of Hizentra = 1.37 x Previous IVIg dose (grams)
Number of weeks between scheduled IVIg doses

Over time, the dose may have to be adjusted to achieve the desired results. To determine if a dose adjustment is needed, measure the patient's serum IgG trough level 2 to 3 months after transitioning to Hizentra. To learn how to adjust the dose, please see the full Prescribing Information.

The goal is to achieve a systemic serum IgG exposure (area under the concentration-time curve) not inferior to that of the previous IVIg treatment.

Use the patient's clinical response as the primary consideration in dose adjustment. Additional dosage increments may be indicated based on the patient's clinical response (infection frequency and severity).

Formulas for converting a weekly Hizentra dose to other frequencies:

Every 2 weeks dose = 2 x weekly dose
Frequent dose Weekly dose
Number of doses per week

Initiating Hizentra therapy for PI

  • Before switching to Hizentra, obtain the patient's serum IgG trough level to guide subsequent dose adjustments
  • Weekly: Start Hizentra 1 week after last Intravenous Immune Globulin (Human) (IVIg) infusion. Initial weekly dose = (Previous IVIg dose [in grams] / No. of weeks between IVIg doses) X 1.37
  • Biweekly (every 2 weeks): Start Hizentra 1 or 2 weeks after the last IVIg infusion or 1 week after the last weekly SCIg infusion. Administer twice the calculated weekly dose
  • Frequent dosing (2 to 7 times per week): Start Hizentra 1 week after the last IVIg or SCIg infusion. Divide the calculated weekly dose by the desired number of times per week
  • Adjust the dose based on clinical response and serum IgG trough levels

Administering Hizentra therapy

Hizentra should be administered subcutaneously only. Do not administer intravenously. Hizentra can be dosed daily up to every 2 weeks for PI using an infusion pump and relatively small needle(s).

Hizentra Injection Sites
  • A Hizentra dose may be infused into multiple injection sites. Use up to 8 sites per infusion. More than one infusion device can be used simultaneously. Infusion sites should be at least 2 inches apart. Change the actual site of infusion with each administration
  • Recommended infusion sites include the abdomen, thighs, upper arms, or side of upper leg/hip
  • SC needles are smaller than IV needles. Depending on a patient's size and weight, a needle as short as 4 mm or as long as 14 mm can be used

Patients infuse less volume with Hizentra than with 10% Ig products

Volume icon
  • Half the volume of 10% Ig products
  • Infused in smaller doses more frequently than IVIg
Based on equivalent dosing in grams.

Encourage patients to start and stay on therapy

Information and resources are available to help patients manage their ongoing administration of Hizentra.

Managing therapy

Frequently asked questions about Hizentra

Want to know more about Hizentra? See answers to prescribers' frequently asked questions.

See the answers
You are now leaving the current website.

Do you want to continue?

No Yes