Woman relaxing on her couch during a Hizentra self-infusion

Starting Hizentra

Self Administration

You Can
DO IT

Self-infuse with confidence.

Infusion Under Your Skin

Hizentra is infused under your skin —
never into a vein

Hizentra is a subcutaneous Ig (SCIg), infused into the fatty tissue just below the top layer of your skin. Remember, you aren’t alone, and Hizentra Connect can send a nurse to your home to help you get confident with self-infusing.

Smaller needles than IVIg*

Illustration of size of SCIg needles relative to IVg needles and a U.S. quarter

Needle lengths are drawn to scale.

*The needle used for Hizentra infusions is relatively small. Depending on your size and weight, your doctor will recommend the appropriate supplies.

Higher Ig concentration means you can infuse smaller volumes than with IVIg

Hizentra is 20% Ig, the highest concentration available and half the volume of 10% Ig (based on an equivalent dose in grams).

Nurse educators are available free of charge

They can answer questions and guide you through every step of your treatment journey. Complete the enrollment form to request help from a nurse educator.

Infusion Sites

Hizentra gives you the flexibility of
multiple infusion sites

You and your healthcare provider can decide which sites work best for you and how many you infuse into.

Infuse into 1 or up to 8 infusion sites

The number of infusion sites used influences the length of time for infusion.

More sites = less time

  • If you are using more than 1 site during a single infusion session, be sure the infusion sites are at least 2 inches apart
  • Use a different site from the one you used last time. It might be helpful to make a note to track the sites you’ve used
  • New sites for future infusions should be at least 1 inch from the previous site

Recommended
infusion sites

  • Abdomen
  • Thighs
  • Upper arms
  • Sides of upper legs or hips
Graphic that shows recommended infusion sites on the body

Self-infusing with
Hizentra Prefilled Syringes

Watch this video on how to self-infuse Hizentra.

Melaine, a patient advocate preparing to self-infuse in her home

Instructions
for Self-Infusing

We’re with you every step of the way.

Download this guide for all the instructions you need for a smooth and easy self-infusion experience.

Download Self-infusion Guide
Cover of Hizentra Self-Infusing brochure

Infusion Tips

Tips for a Positive
Self-Infusion Session

Get Comfortable

Let others know your infusion schedule to reduce interruptions. Use this time to read, watch TV, or relax in another way.

Prepare Your Supplies

If you're new to infusions, review the instructions provided by your healthcare provider to ensure you're clear on the process and have all the necessary supplies to self-infuse.

Stay Hydrated

Drink water before starting and keep a beverage nearby in case you get thirsty during the infusion.

Follow Doctor's Orders

Stick to the prescribed dose and infusion schedule, as directed by your PI healthcare provider.

Be Aware of Side Effects

Mild pain, swelling, or redness at the infusion site are common but usually temporary. Headaches, nausea, fatigue, and other side effects may occur. Report any side effects that you experience to your healthcare provider.

Record Details

Note down infusion times, dose, lot number(s), and any reactions to share with your PI healthcare provider.

Phones featuring the Hizentra app

Hizentra app

Track infusions more easily
with the Hizentra app

  • Schedule personalized infusion reminders
  • Scan label(s) and track infusion details
  • Share your infusion history with your PI healthcare provider

Need Help
with Infusing?

Get personalized support with a trained nurse who will come to your home for up to 4 visits to help you gain confidence with self-infusion.

To enroll, call 1-877-355-4447, Mon-Fri, 8 AM-8 PM ET.

Or, you can start your enrollment online today.

Doctor talking to a woman on a couch

Check out the additional resources available to you

Important Safety Information

WARNING: Thrombosis (blood clots) can occur with immune globulin products, including Hizentra. Risk factors can include: advanced age, prolonged immobilization, a history of blood clotting or hyperviscosity (blood thickness), use of estrogens, installed vascular catheters, and cardiovascular risk factors.

If you are at high risk of blood clots, your doctor will prescribe Hizentra at the minimum dose and infusion rate practicable and will monitor for signs of clotting events and hyperviscosity. Always drink sufficient fluids before infusing Hizentra.

See your doctor for a full explanation, and the full prescribing information for complete boxed warning.

Hizentra®, Immune Globulin Subcutaneous (Human), 20% Liquid, is a prescription medicine used to treat:

  • Primary immune deficiency (PI) in patients 2 years and older
  • Chronic inflammatory demyelinating polyneuropathy (CIDP) in adults

Treatment with Hizentra might not be possible if your doctor determines you have hyperprolinemia (too much proline in the blood), or are IgA-deficient with antibodies to IgA and a history of hypersensitivity. Tell your doctor if you have previously had a severe allergic reaction (including anaphylaxis) to the administration of human immune globulin. Tell your doctor right away or go to the emergency room if you have hives, trouble breathing, wheezing, dizziness, or fainting. These could be signs of a bad allergic reaction.

Inform your doctor of any medications you are taking, as well as any medical conditions you may have had, especially if you have a history of diseases related to the heart or blood vessels, or have been immobile for some time. Inform your physician if you are pregnant or nursing, or plan to become pregnant.

Infuse Hizentra under your skin only; do not inject into a blood vessel.

Self-administer Hizentra only after having been taught to do so by your doctor or other healthcare professional, and having received dosing instructions for treating your condition.

Immediately report to your physician any of the following symptoms, which could be signs of serious adverse reactions to Hizentra:

  • Reduced urination, sudden weight gain, or swelling in your legs (possible signs of a kidney problem).
  • Pain and/or swelling or discoloration of an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, or numbness/weakness on one side of the body (possible signs of a blood clot).
  • Bad headache with nausea; vomiting; stiff neck; fever; and sensitivity to light (possible signs of meningitis).
  • Brown or red urine; rapid heart rate; yellowing of the skin or eyes; chest pains or breathing trouble; fever over 100°F (possible symptoms of other conditions that require prompt treatment).

Hizentra is made from human blood. The risk of transmission of infectious agents, including viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent and its variant (vCJD), cannot be completely eliminated.

The most common side effects in the clinical trials for Hizentra include redness, swelling, itching, and/or bruising at the infusion site; headache; chest, joint or back pain; diarrhea; tiredness; cough; rash; itching; fever, nausea, and vomiting. These are not the only side effects possible. Tell your doctor about any side effect that bothers you or does not go away.

Before receiving any vaccine, tell immunizing physician if you have had recent therapy with Hizentra, as effectiveness of the vaccine could be compromised.

Please see full prescribing information for Hizentra, including boxed warning and the patient product information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

You can also report side effects to CSL Behring's Pharmacovigilance Department at 1-866-915-6958.

View information about Hizentra for:
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