Frequently asked
questions

Ig therapy is generally delivered in one of two ways. Intravenous Ig therapy, or IVIg, is administered into the vein by a medical professional. Patients with PI typically receive IVIg once every 3–4 weeks. Maintenance IVIg therapy for CIDP is often administered once every 3 weeks.

Subcutaneous Ig therapy, or SCIg, is infused into the fatty layer under the skin (not into a vein). Hizentra is a SCIg therapy. With proper training, most patients can self-infuse Hizentra or receive assistance from a caregiver. For CIDP, Hizentra is infused weekly. For PI, Hizentra may be infused daily or up to every 2 weeks. Talk with your healthcare provider about the dosing option that's right for you.

As a 20% SCIg therapy, Hizentra has the highest concentration of immunoglobulin available in a SCIg treatment, so you can receive the Ig treatment while infusing a lower volume, which potentially could result in fewer needlesticks. Hizentra was specifically designed to deliver Ig levels in half the volume of 10% Ig products,* regardless of which dosing schedule you and your healthcare provider choose.

*Based on an equivalent dose in grams.

Hizentra can be stored at room temperature (up to 25°C [77°F]) for up to 30 months, up to the expiration date printed on the outer carton of the prefilled syringe. This means you don't have to worry about refrigerating Hizentra at home or when you are on the go.

The amount of Hizentra you infuse per month will not change, regardless of how often you infuse.

How long each infusion takes may vary based on a number of factors, including how often you infuse, the number of infusion sites you use, your infusion rate, and other factors. You and your doctor can decide what is best for you.

For PI, you can have infusions as often as every day up to every 2 weeks.

For CIDP, infusions are given once weekly (in 1–2 sessions over 1–2 consecutive days).

The most common side effects in the clinical trials for Hizentra include redness, swelling, itching, and/or bruising at the infusion site; headache; chest, joint or back pain; diarrhea; tiredness; cough; rash; itching; fever, nausea, and vomiting. These are not the only side effects possible. Tell your doctor about any side effects that you may experience.

Hizentra is the first and only Ig available in prefilled syringes. While vials may still be available, prefilled syringes may be a convenient option for some people. Prefilled syringes may also simplify the set-up and transfer of Hizentra for those who have difficulty drawing from vials.

Your doctor can help you decide whether prefilled syringes are right for you.

Travel may be easier with a first and only for Ig—Hizentra Prefilled Syringes.

In a CSL-sponsored Harris Poll survey, 91% of people with PI were satisfied with the ease of travel with prefilled syringes. 70% of people with CIDP reported that prefilled syringes had a very or somewhat positive impact on their ability to travel.*

Whether you’re traveling for pleasure or business—across the state or around the globe—a few simple preparations can help keep you safe:

• Bring enough medication to last the length of your trip
• If flying, take medication with you on the plane
• Keep medications at the right temperature†
• Identify the healthcare resources at your destination

For international travel, you may want to make a few extra preparations:

• Have any items with medical information translated into the language spoken at your destination
• Familiarize yourself with the security policies at any foreign airport you travel through, as they may be substantially different than in US airports

^*In an online survey, 30 of 33 adults with PI who have self-infused Ig using prefilled syringes were very/somewhat satisfied with ease of travel; 37 of 53 of those with CIDP reported that prefilled syringes had a very/somewhat positive impact on their ability to travel.

^†Hizentra should be stored at room temperature—up to 77°F (25°C). Hizentra is stable for up to 30 months, as indicated by the expiration date printed on the outer carton of the prefilled syringe or vial label.

We are working to have Hizentra covered by as many health insurance formularies as possible. 95% of people with insurance are covered for Hizentra. Hizentra Connect℠ can also help you by doing a full benefits investigation to help you understand your options and how much they cost, identify managed care reimbursement opportunities, and talk to you about financial assistance if you're uninsured.

Hizentra is covered under Medicare Part B for CIDP and some types of PI.* Get the convenience of self-infused Hizentra, covered under the same benefit category as IVIg.^† Medicare Part B coverage means lower out-of-pocket costs for you than with Part D, covering pump, supplies, medication, and nurse training.

We can help, even if Medicare Part B wasn't an option before. To get started, call Hizentra Connect℠ at 1-877-355-4447, Monday‑Friday, 8 AM to 8 PM ET.

^*100% coverage for those with Medicare Part B and a Medigap plan after Part B annual deductible is met.

^†Coverage of IVIg when administered in a clinical setting.

The cost of any treatment, including Hizentra, depends on a number of factors, including insurance status and the insurer's copay/coinsurance policy. The actual out-of-pocket cost to a patient will depend on their individual prescription and medical coverage.

For those who cannot afford their treatment, CSL Behring is committed to providing appropriate resources to ensure patients can begin and/or remain on their therapy. These include:

Continued Treatment After Insurance Loss–This program may be able to help you continue to receive treatment even if you experience a lapse in third-party private health insurance. Eligible patients earn points for Hizentra that you can use to secure medicine should you have a lapse in your third-party private health insurance. It is free and features easy enrollment and participation.*

Copay Support Program–Most eligible people with commercial insurance pay $0 in out-of-pocket expenses for Hizentra.^†

Patient Assistance Program–Offers help if you are uninsured or underinsured, or otherwise can't afford Hizentra therapy. For more information, including program terms and conditions, call the Hizentra Connect℠ resource center, CSL Behring's single source for information about immunoglobulin therapies, at 1-877-355-4447, Monday‑Friday, 8 AM to 8 PM ET.

^*Enrollment required. Subject to terms and conditions. For the Assurance Program, visit www.csl.com/patients-public-health/patient-support-and-organizations/csl-behring-usa-support-and-assistance-programs

^†Subject to terms and conditions of the Copay Support Program. To read the full terms and conditions, click here. CSL Behring reserves the right to rescind, revoke, or amend the program at any time without notice.

If you and your doctor have decided you're ready to try Hizentra, you may be able to get a 1-month supply of medicine, infusion equipment, and in–home nurse training for free.

To apply for this program, ask your doctor to call Hizentra Connect℠ to see if you are eligible. For more information, call 1-877-355-4447, Monday‑Friday, 8 AM to 8 PM ET.

The Hizentra app means your infusion log is never farther away than your phone! The Hizentra app allows you to schedule personalized infusion reminders, and track your infusion details from the palm of your hand. Tracking your infusions allows you to share your detailed history with your doctor and make any necessary changes to your therapy and personalize treatment to your specific responses and needs.

If you currently use the MyHizentra^® Infusion Manager app, you will be transferred to the new Hizentra app during regular app updates. Upon launching the new app, current MyHizentra^® Infusion Manager app users will be asked to confirm their profile so it can be migrated seamlessly into the new app.

Download the Hizentra app and start tracking today!

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If you are a Hizentra patient or caregiver, you can sign up for Voice2Voice, a unique program from CSL Behring that provides the opportunity for patients and caregivers to connect and share their experience firsthand.*

^*Voice2Voice advocates are not healthcare providers or medical experts. For medical questions, please contact your physician. Voice2Voice advocates are compensated by CSL Behring LLC. for their time and/or expenses.

Contact Hizentra Connect℠, who will conduct a full benefits investigation and assist in resolving the problem.

Several patient organizations have websites with information that may be helpful. Patients with PI can visit the Immune Deficiency Foundation (IDF) website, a global patient organization for patients with PI. Patients with CIDP can visit the GBS/CIDP Foundation website, a global patient organization for patients with CIDP.