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Starting Hizentra

Self-administering Hizentra

self-administering
Hizentra for CIDP

Overview

How to
Self-administer Hizentra

Hizentra is a subcutaneous immunoglobulin, or SCIg, which means it is infused into the fatty layer located just under the skin, and NOT in a vein.

Diagram of skin layer for location on where to self-administer Hizentra

Prefilled Syringes

How do I infuse?

Before you can self-infuse Hizentra, you will need proper training from a healthcare professional. Several resources are available here to help you and your doctor make sure you're comfortable with the self-infusion process.

Watch the instruction videos here or download the self-administration guide to review the step-by-step instructions on preparation, proper infusion techniques, and administration.

Melaine, a patient advocate preparing to self-infuse in her home

Infusion Sites

Your choice of
infusion sites

You can use up to 8 infusion sites at the same time. In clinical trials, most patients used 4 or fewer infusion sites. If you are using more than one infusion site, be sure the infusion sites are at least 2 inches apart. Use a different site from the last time you infused. New sites should be at least 1 inch from a previous site.

Discuss any questions you may have about selecting an appropriate infusion site(s) with your doctor.

Recommended
infusion sites

  • Abdomen
  • Thighs
  • Upper arms
  • Sides of upper legs or hips
Graphic that shows recommended infusion sites on the body

INFUSION UNDER YOUR SKIN

Hizentra is infused under your skin—
never into a vein

Hizentra is a subcutaneous Ig (SCIg), infused into the fatty tissue just below the top layer of your skin. Remember, you aren't alone, and Hizentra Connect can send a nurse to your home to help you get confident with self-infusing.

Smaller needles than IVIg*

Illustration of size of SCIg needles relative to IVg needles and a U.S. quarter

Needle lengths are drawn to scale.

*The needle used for Hizentra infusions is relatively small. Depending on your size and weight, your doctor will recommend the appropriate supplies.

Prefilled syringes and available in 1g, 2g,, 4g, and 10g doses

Simple, convenient, and ready to use

  • Simplifies infusion preparation vs. vials
  • Wide range of sizes for your individual needs
  • Select sizes are directly compatible with common infusion pumps
    • All sizes can be transferred to a pump-compatible syringe using a syringe-to-syringe transfer device
    • Ask your specialty pharmacy if Hizentra Prefilled syringes are compatible with your infusion pump
Phones featuring the Hizentra app

Hizentra app

Track infusions more easily
with the Hizentra app

The Hizentra app gives you the freedom and flexibility to set treatment reminders and record infusion details right in the palm of your hand.

  • Schedule personalized infusion reminders
  • Scan label(s) and track infusion details
  • Share your infusion history with your PI healthcare provider
Nurse talking to a patient

Support from a Nurse

Clinical Nurse Education

Join today for personalized support on your self-infusion journey. This includes helping you get your Hizentra, explaining the self-administration process, and providing information about financial and other important resources.

Enroll now
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Savings
and support

From in-home nurse training visits to financial support and insurance navigation, free help is available so you can live confidently.

To learn more, call 1-877-355-4447 to enroll, Mon–Fri, 8 AM–8 PM ET. Or, you can start your enrollment online today.

Learn more about getting the support you need

Important Safety Information

WARNING: Thrombosis (blood clots) can occur with immune globulin products, including Hizentra. Risk factors can include: advanced age, prolonged immobilization, a history of blood clotting or hyperviscosity (blood thickness), use of estrogens, installed vascular catheters, and cardiovascular risk factors.

If you are at high risk of blood clots, your doctor will prescribe Hizentra at the minimum dose and infusion rate practicable and will monitor for signs of clotting events and hyperviscosity. Always drink sufficient fluids before infusing Hizentra.

See your doctor for a full explanation, and the full prescribing information for complete boxed warning.

Hizentra®, Immune Globulin Subcutaneous (Human), 20% Liquid, is a prescription medicine used to treat:

  • Primary immune deficiency (PI) in patients 2 years and older
  • Chronic inflammatory demyelinating polyneuropathy (CIDP) in adults

Treatment with Hizentra might not be possible if your doctor determines you have hyperprolinemia (too much proline in the blood), or are IgA-deficient with antibodies to IgA and a history of hypersensitivity. Tell your doctor if you have previously had a severe allergic reaction (including anaphylaxis) to the administration of human immune globulin. Tell your doctor right away or go to the emergency room if you have hives, trouble breathing, wheezing, dizziness, or fainting. These could be signs of a bad allergic reaction.

Inform your doctor of any medications you are taking, as well as any medical conditions you may have had, especially if you have a history of diseases related to the heart or blood vessels, or have been immobile for some time. Inform your physician if you are pregnant or nursing, or plan to become pregnant.

Infuse Hizentra under your skin only; do not inject into a blood vessel.

Self-administer Hizentra only after having been taught to do so by your doctor or other healthcare professional, and having received dosing instructions for treating your condition.

Immediately report to your physician any of the following symptoms, which could be signs of serious adverse reactions to Hizentra:

  • Reduced urination, sudden weight gain, or swelling in your legs (possible signs of a kidney problem).
  • Pain and/or swelling or discoloration of an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, or numbness/weakness on one side of the body (possible signs of a blood clot).
  • Bad headache with nausea; vomiting; stiff neck; fever; and sensitivity to light (possible signs of meningitis).
  • Brown or red urine; rapid heart rate; yellowing of the skin or eyes; chest pains or breathing trouble; fever over 100°F (possible symptoms of other conditions that require prompt treatment).

Hizentra is made from human blood. The risk of transmission of infectious agents, including viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent and its variant (vCJD), cannot be completely eliminated.

The most common side effects in the clinical trials for Hizentra include redness, swelling, itching, and/or bruising at the infusion site; headache; chest, joint or back pain; diarrhea; tiredness; cough; rash; itching; fever, nausea, and vomiting. These are not the only side effects possible. Tell your doctor about any side effect that bothers you or does not go away.

Before receiving any vaccine, tell immunizing physician if you have had recent therapy with Hizentra, as effectiveness of the vaccine could be compromised.

Please see full prescribing information for Hizentra, including boxed warning and the patient product information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

You can also report side effects to CSL Behring's Pharmacovigilance Department at 1-866-915-6958.

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