With Hizentra

Personalized dosing
more freedom^* than ever before

Personalized Dosing

Ig protection without the IV – Hizentra gives you
the freedom to self-infuse when and where you choose.^†

Flexible dosing (daily up to every 2 weeks) means no more adjusting your schedule or canceling plans to keep IVIg appointments.

*Vs treating with IVIg.
^†Please consult your doctor or healthcare provider before making any medical decisions.

Personalized to fit
your specific needs:

How often you infuse
How long infusions take
How much medicine per infusion
How many infusion sites

Learn how people living with PI
have overcome their burdens

Clinical Challenges

After his monthly IVIg infusions, Ben’s Mom said he would feel extremely energetic, but 2 to 2.5 weeks later, he’d crash from fatigue. At week 3 to 4, he would then get infections. She describes it as a monthly rollercoaster for the family—high highs followed by a crash and then needing to care for a child who was sick and miserable. Ben was switched to Hizentra, which now keeps his Ig levels the same all the time without the huge ups and downs.

Dose: 5 g/25 mL
Infusion sites: 1
Time per infusion: ~1 hour^‡

Marie is a grandmother of three who enjoys baking, knitting, and playing cards. Marie's veins were in poor shape after years of IVIg, so she talked to her doctor and decided to start Hizentra. Marie finds it easy to remember to infuse every 2 weeks and prefers the convenience of using Hizentra Prefilled Syringes.

Dose: 16 g/80 mL
Infusion sites: 4
Time per infusion: ~48 minutes^‡

Ian is a marketing professional who loves to read in his free time. His previous IVIg dose of 40 grams required a large volume for each infusion that made him uncomfortable at times, so he spoke with his doctor and decided to try more frequent doses with Hizentra. Infusing once a week means less volume and time per infusion for Ian.

Dose: 14 g/70 mL
Infusion sites: 3
Time per infusion: ~1 hour^‡

Lifestyle Burdens

Sarah is a working mom with 2 kids who doesn't have much spare time. She spoke to her doctor and switched to Hizentra because she needs an infusion schedule that offers flexibility and freedom to fit the needs of her busy life. Sara uses prefilled syringes since they may simplify her infusions.

Dose: 10 g/50 mL
Infusion sites: 2
Time per infusion: ~1 hour^‡

Anthony is an active college student who enjoys sports and video games and recently transferred to a new campus. The new distance from his IV clinic meant getting there was a hassle, so he and his doctor decided to try Hizentra. Because of his activity level and low body fat, they decided on a frequent infusion schedule, resulting in less volume and shorter infusions. Anthony and his doctor chose prefilled syringes since they may make his self-infusion process more convenient.

Dose: 6 g/30 mL
Infusion sites: 2
Time per infusion: ~38 minutes^‡

^‡Infusion times may vary and are dependent on the pump brand and type of syringe used.

^§Rate of infusion and number of infusion sites in these hypothetical people with PI are based on recommended rate and volume per site of subsequent infusions. Photos do not depict actual patients.

I learned that feeling sick half the month wasn’t ideal. I didn’t have to accept the highs and lows.

Janet

Patient advocate^¶ on Hizentra

Prefilled Syringes

They're simple, convenient,
and we delivered them to you first!

Hizentra has been making prefilled syringes available for over 5 years to simplify the infusion process with:

No more vial transfer, which is often challenging for many
Fewer preparation steps vs vials, which may reduce the chance of error
Wide range of sizes for your individual needs
Select sizes are directly compatible with common infusion pumps
All sizes can be transferred to a pump syringe using a syringe-to-syringe transfer device

Prefilled syringes and available in 1g, 2g,, 4g, and 10g doses

Patient talking to their PI healthcare provider

Discussion Guide

Need help speaking with your
PI healthcare provider?

See tips on how to effectively communicate your experience.

Hizentra discussion guide

^¶Patient advocates are not healthcare providers or medical experts. For medical questions, please contact your physician. Patient advocates are compensated by CSL Behring LLC for their time and/or expenses.

Check out the most frequently asked questions

Important Safety Information

WARNING: Thrombosis (blood clots) can occur with immune globulin products, including Hizentra. Risk factors can include: advanced age, prolonged immobilization, a history of blood clotting or hyperviscosity (blood thickness), use of estrogens, installed vascular catheters, and cardiovascular risk factors.

If you are at high risk of blood clots, your doctor will prescribe Hizentra at the minimum dose and infusion rate practicable and will monitor for signs of clotting events and hyperviscosity. Always drink sufficient fluids before infusing Hizentra.

See your doctor for a full explanation, and the full prescribing information for complete boxed warning.

Hizentra^®, Immune Globulin Subcutaneous (Human), 20% Liquid, is a prescription medicine used to treat:

Primary immune deficiency (PI) in patients 2 years and older
Chronic inflammatory demyelinating polyneuropathy (CIDP) in adults

Treatment with Hizentra might not be possible if your doctor determines you have hyperprolinemia (too much proline in the blood), or are IgA-deficient with antibodies to IgA and a history of hypersensitivity. Tell your doctor if you have previously had a severe allergic reaction (including anaphylaxis) to the administration of human immune globulin. Tell your doctor right away or go to the emergency room if you have hives, trouble breathing, wheezing, dizziness, or fainting. These could be signs of a bad allergic reaction.

Inform your doctor of any medications you are taking, as well as any medical conditions you may have had, especially if you have a history of diseases related to the heart or blood vessels, or have been immobile for some time. Inform your physician if you are pregnant or nursing, or plan to become pregnant.

Infuse Hizentra under your skin only; do not inject into a blood vessel.

Self-administer Hizentra only after having been taught to do so by your doctor or other healthcare professional, and having received dosing instructions for treating your condition.

Immediately report to your physician any of the following symptoms, which could be signs of serious adverse reactions to Hizentra:

Reduced urination, sudden weight gain, or swelling in your legs (possible signs of a kidney problem).
Pain and/or swelling or discoloration of an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, or numbness/weakness on one side of the body (possible signs of a blood clot).
Bad headache with nausea; vomiting; stiff neck; fever; and sensitivity to light (possible signs of meningitis).
Brown or red urine; rapid heart rate; yellowing of the skin or eyes; chest pains or breathing trouble; fever over 100°F (possible symptoms of other conditions that require prompt treatment).

Hizentra is made from human blood. The risk of transmission of infectious agents, including viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent and its variant (vCJD), cannot be completely eliminated.

The most common side effects in the clinical trials for Hizentra include redness, swelling, itching, and/or bruising at the infusion site; headache; chest, joint or back pain; diarrhea; tiredness; cough; rash; itching; fever, nausea, and vomiting. These are not the only side effects possible. Tell your doctor about any side effect that bothers you or does not go away.

Before receiving any vaccine, tell immunizing physician if you have had recent therapy with Hizentra, as effectiveness of the vaccine could be compromised.

Please see full prescribing information for Hizentra, including boxed warning and the patient product information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

You can also report side effects to CSL Behring's Pharmacovigilance Department at 1-866-915-6958.

Personalized dosing
more freedom^* than ever before

Ig protection without the IV – Hizentra gives you
the freedom to self-infuse when and where you choose.^†