Grocery story worker in an apron helping a customer

Why Hizentra | Results

Primary Immunodeficiency (PI)

LESS OF WHAT  YOU DON'T WANT.
MORE OF WHAT YOU DO.

Vs treating with IVIg

Infection Protection

Proven Protection
against infection

NO
serious bacterial infections*

In a 12-month study, Hizentra delivered low rates of infection with no serious infections that could potentially require hospitalization, including:

  • bacterial pneumonia
  • bacteremia/septicemia
  • osteomyelitis/septic arthritis
  • bacterial meningitis
  • visceral abscess

FEWER
than 3 overall infections/year

In the same 12-month study, participants experienced an average of 2.76 overall infections per subject-year.

ONLY 2
missed days/year

People taking Hizentra missed about 2 days of work or school per year, on average, due to infections. (2.06 days per person per year in clinical studies.)

Does not include missed days going to the infusion center.

*Serious bacterial infections were defined as bacterial pneumonia, bacteremia/septicemia, osteomyelitis/septic arthritis, bacterial meningitis, and visceral abscess.

Steady Ig Levels

Are the ups and downs
in your Ig levels affecting you?

Hizentra helps you maintain steady Ig levels, which can make a difference in how you feel.

IVlg

With IVIg dosing every 3-4 weeks, you may experience highs and lows between infusions.

Hizentra

Hizentra dosing helps maintain steady Ig levels that closely resemble normal levels. More steady Ig levels may reduce potential for side effects between infusions.

SAFETY & EFFECTIVENESS

The subcutaneous lg with the longest record of proven safety and effectiveness in PI

No serious side effects in the Hizentra US clinical study

In the 12-month study of people taking Hizentra to treat PI, there were no serious side effects related to treatment. Two subjects withdrew from the 12-month study due to non-serious side effects.

The most common side effects in the clinical trials for Hizentra included redness, swelling, itching, and/or bruising at the infusion site; headache; chest, joint or back pain; diarrhea; tiredness; cough; rash; itching; fever; nausea; and vomiting. These side effects were typically described as mild or moderate and were reported less often over time.

All Ig treatments, including Hizentra, come with inherent risks, the most serious being thrombosis (blood clotting). Talk to your doctor to see if you are at risk for thrombosis, and read the Important Safety Information before taking Hizentra.

15+ YEARS
of proven safety and effectiveness in PI

NO
serious side effects related to treatment

FEWER
than 0.4%
of local reactions were severe

Mild=Does not interfere with routine activities; Moderate=Interferes somewhat with routine activities; Severe=Interrupts routine activities or may require intensive therapeutic intervention.

Real Stories

Meet
Melaine

Patient advocate§ on Hizentra

With Hizentra, I get to live the life that I've always wanted. I don't feel like a victim of my disease. I really feel more like a victor and that is amazing.”

See more stories
Melaine, a patient advocate on Hizentra
Hizentra Connect℠ logo

Dealing with insurance can be hard.
Get the support you need.

From in-home nurse training visits to financial support and insurance navigation, free help is available so you can live confidently.

To learn more, call 1-877-355-4447 to enroll, Mon–Fri, 8 AM–8 PM ET. Or, you can start your enrollment online today.

§Patient advocates are not healthcare providers or medical experts. For medical questions, please contact your physician. Patient advocates are compensated by CSL Behring LLC for their time and/or expenses.

Find a treatment that can be personalized for you.

Important Safety Information

WARNING: Thrombosis (blood clots) can occur with immune globulin products, including Hizentra. Risk factors can include: advanced age, prolonged immobilization, a history of blood clotting or hyperviscosity (blood thickness), use of estrogens, installed vascular catheters, and cardiovascular risk factors.

If you are at high risk of blood clots, your doctor will prescribe Hizentra at the minimum dose and infusion rate practicable and will monitor for signs of clotting events and hyperviscosity. Always drink sufficient fluids before infusing Hizentra.

See your doctor for a full explanation, and the full prescribing information for complete boxed warning.

Hizentra®, Immune Globulin Subcutaneous (Human), 20% Liquid, is a prescription medicine used to treat:

  • Primary immune deficiency (PI) in patients 2 years and older
  • Chronic inflammatory demyelinating polyneuropathy (CIDP) in adults

Treatment with Hizentra might not be possible if your doctor determines you have hyperprolinemia (too much proline in the blood), or are IgA-deficient with antibodies to IgA and a history of hypersensitivity. Tell your doctor if you have previously had a severe allergic reaction (including anaphylaxis) to the administration of human immune globulin. Tell your doctor right away or go to the emergency room if you have hives, trouble breathing, wheezing, dizziness, or fainting. These could be signs of a bad allergic reaction.

Inform your doctor of any medications you are taking, as well as any medical conditions you may have had, especially if you have a history of diseases related to the heart or blood vessels, or have been immobile for some time. Inform your physician if you are pregnant or nursing, or plan to become pregnant.

Infuse Hizentra under your skin only; do not inject into a blood vessel.

Self-administer Hizentra only after having been taught to do so by your doctor or other healthcare professional, and having received dosing instructions for treating your condition.

Immediately report to your physician any of the following symptoms, which could be signs of serious adverse reactions to Hizentra:

  • Reduced urination, sudden weight gain, or swelling in your legs (possible signs of a kidney problem).
  • Pain and/or swelling or discoloration of an arm or leg, unexplained shortness of breath, chest pain or discomfort that worsens on deep breathing, unexplained rapid pulse, or numbness/weakness on one side of the body (possible signs of a blood clot).
  • Bad headache with nausea; vomiting; stiff neck; fever; and sensitivity to light (possible signs of meningitis).
  • Brown or red urine; rapid heart rate; yellowing of the skin or eyes; chest pains or breathing trouble; fever over 100°F (possible symptoms of other conditions that require prompt treatment).

Hizentra is made from human blood. The risk of transmission of infectious agents, including viruses and, theoretically, the Creutzfeldt-Jakob disease (CJD) agent and its variant (vCJD), cannot be completely eliminated.

The most common side effects in the clinical trials for Hizentra include redness, swelling, itching, and/or bruising at the infusion site; headache; chest, joint or back pain; diarrhea; tiredness; cough; rash; itching; fever, nausea, and vomiting. These are not the only side effects possible. Tell your doctor about any side effect that bothers you or does not go away.

Before receiving any vaccine, tell immunizing physician if you have had recent therapy with Hizentra, as effectiveness of the vaccine could be compromised.

Please see full prescribing information for Hizentra, including boxed warning and the patient product information.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

You can also report side effects to CSL Behring's Pharmacovigilance Department at 1-866-915-6958.

View information about Hizentra for:
You are leaving the current website.

The site you are accessing is maintained by a third party over whom CSL Behring has no control. CSL Behring does not review, approve, or necessarily endorse viewpoints, inferences, or conclusions stated in or implied by the content of this site. CSL Behring is not responsible for third-party content or the consequences of your use thereof.

Do you want to continue?