EAN/PNS* guideline on diagnosis and treatment of CIDP “strongly recommends” SCIg for CIDP maintenance19

Watch Dr. Peter Van den Bergh, lead author, take you through the EAN/PNS guideline highlights.

CIDP Efficacy and Safety

Proven in the largest trial of CIDP and further evaluated in an extension study

First and Only FDA-Approved Subcutaneous Ig for CIDP maintenance
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EAN/PNS guideline recommends tailoring SCIg dose according to individual treatment response19

Largest Study in CIDP (n=172)

See the study design of PATH and
the Open-Label Extension (OLE) to PATH5,14

CIDP Pivotal Trial and Open-Label Extension Study Chart CIDP Pivotal Trial and Open-Label Extension Study Chart
PATH Pivotal Trial design: Data from a randomized, multicenter, double-blind, placebo-controlled, parallel-group, phase III study of 2 doses of weekly Hizentra versus placebo for the treatment of chronic inflammatory demyelinating polyneuropathy (CIDP)—the PATH Study. Subjects who relapsed during the postrandomized phase were to receive IVIg as a rescue medication within 1 week. CIDP relapse was defined as a ≥1-point increase in adjusted Inflammatory Neuropathy Cause and Treatment (INCAT) score compared with baseline. OLE to PATH Study design: 48-week, open-label, prospective extension study to PATH. 82 patients were enrolled: 62 patients were started on 0.4 g/kg weekly infusion of Hizentra, and 20 patients were started on 0.2 g/kg weekly. If clinically stable, patients on 0.4 g/kg were switched to 0.2 g/kg after 24 weeks. Upon CIDP relapse on 0.2 g/kg dose, 0.4 g/kg was either initiated or reinitiated. CIDP relapse defined as a ≥1-point increase in adjusted inflammatory Neuropathy Cause and Treatment (INCAT) score compared with baseline. Enrollment into the extension study started in 2014, more than 2 years after the start of the PATH study. Most patients had a time gap between completion of PATH and entry into the extension study during which they were treated with IVIG.
Frequently asked questions about Hizentra for CIDP

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Frequently asked questions about CIDP
Flexibility with Hizentra self-administration for CIDP

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