Dosing and Administration

Self-administered Hizentra lets you plan treatment around your patient's life

Your patients are all different and deserve a treatment with the flexibility to fit their individual needs and preferences. Use the guidelines and dosing calculator below to initiate a patient's Hizentra therapy. Monitor the patient's clinical response and adjust the duration of therapy based on patient need.

Adjustable dosing offers greater flexibility when tailoring patient treatment to individual needs

CIDP dosing calculator

1

Calculate Weekly Dose

Enter CIDP patient's weight

lb

kg

Please enter a value between 1 and 499.

Enter dose (g/kg)
Recommended dose is 0.2 g/kg or 0.4 g/kg

Please enter a value between 0.1 and 1.0.

2

Calculate Infusion Time

Weekly dose XX g (XX mL)

Reset

Select rate per site (mL/hr/site)

5
(min)

50
(max)

–

+

Enter infusion volume or number of sites

Volume per site

Number of infusion sites

Infusion volume (mL/site)

5
(min)

50
(max)

–

+

Number of infusion sites

sites

Number of sites cannot exceed 8 sites per infusion (per Hizentra Prescribing Information).
Please select a larger infusion volume or consider multiple infusion sites over multiple days.

Number of infusion sites

1
(min)

8
(max)

–

+

Infusion volume

25 mL/site

Volume of infusions per site cannot exceed 50 mL (per Hizentra Prescribing Information).
Please select a higher number of infusion sites or consider multiple sessions over multiple days.

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Dosing Results

Infusion time*: XX hours and XX minutes Weekly dose XX g (XX mL)

Your results are based on a patient weight of XXX XX and dose of X.X g/kg

To see number of vials, select vial size:

1 g (5 mL)

2 g (10 mL)

4 g (20 mL)

10 g (50 mL)

Number of vials: XXX

*Infusion times can vary based on specific equipment used.

Formula used to calculate the weekly dose in mL from the patient's weight in kg:

Weekly dose
calculation

Weekly volume
calculation

Patient body weight (in kg)
× dose (0.2 or 0.4 g/kg)
= weekly dose (in g)

Weekly dose (in g) ×
5 mL/1 g = volume (in mL)

Sample weekly
dosing calculations
for an 80-kg patient

0.2 g/kg

0.4 g/kg

80 kg × 0.2 g/kg = 16 g

80 kg × 0.4 g/kg = 32 g

16 g × 5 mL/1 g = 80 mL

32 g × 5 mL/1 g = 160 mL

Initiate therapy 1 week after last IVIg infusion

Recommended subcutaneous dose is 0.2 g/kg body weight per week
- A dose of 0.4 g/kg body weight per week was also safe and effective
If CIDP symptoms worsen on 0.2 g/kg consider increasing to 0.4 g/kg per week
Most patients remained relapse-free on either dosing option, with the 0.4 g/kg dose showing a lower rate of relapse^*†
- If CIDP symptoms worsen on the 0.4 g/kg dose, consider reinitiating therapy with IVIg

EAN/PNS guideline recommends tailoring SCIg dose according to individual treatment response¹⁹

* CIDP relapse was defined as a ≥1-point increase in adjusted Inflammatory Neuropathy Cause and Treatment [INCAT] score compared with baseline. † Statistical tests between the two doses were not conducted.

Proactively monitor and optimize therapy

Monitor the patient's clinical response and adjust the duration of therapy based on patient need
Volume and rate can be adjusted after initial infusion as tolerated, which may decrease infusion time and number of sites
Consider changing one variable at time (eg, rate, volume, ancillary supplies, site) to continue tailoring treatment for your patient
Hizentra may be infused in up to 8 infusion sites simultaneously, depending on volume

Administering Hizentra therapy

Administration volumes and rates for Hizentra (as tolerated)

Infusion parameters*	1st infusion	Subsequent infusions
Volume (mL/site)	≤20	≤50

Rate (mL/hr/site)	≤20	≤50

*As tolerated

Hizentra should be administered subcutaneously only. Do not administer intravenously. Hizentra can be administered weekly for CIDP in 1 or 2 sessions over 1 or 2 consecutive days, using an infusion pump and relatively small needle(s).

A Hizentra dose may be infused into multiple injection sites. Use up to 8 sites per infusion. More than one infusion device can be used simultaneously. Infusion sites should be at least 2 inches apart. Change the actual site of infusion with each administration
Recommended infusion sites include the abdomen, thighs, upper arms, or side of upper leg/hip
SC needles are smaller than IV needles. Depending on a patient's size and weight, a needle as short as 4 mm or as long as 14 mm can be used

See how easy self-administration can be with Hizentra

Self-infusing with Hizentra prefilled syringes

Self-infusing with Hizentra vials

Download our step-by-step guide to
administration using a pump

Become a SHARE Hizentra administration specialist:

Complete training in about 1 hour at your convenience
Get a certificate of completion
Add your practice to the Nurse Locator so patients in your area can find you!

Start your SHARE training

Encourage patients to start and stay on therapy

Information and resources are available to help patients manage their ongoing administration of Hizentra.

Managing therapy

Frequently asked questions about Hizentra

Want to know more about Hizentra? See answers to prescribers' frequently asked questions.

See the answers